Optimization of a method for preparing solid complexes of essential clove oil with beta-cyclodextrins

Abstract

Essential CO was successfully solubilized in aqueous solution by forming inclusion complexes with beta-cyclodextrins (beta-CDs). Moreover, phase solubility studies demonstrated that essential CO also forms insoluble complexes with beta-CDs. Based on these results, essential CO-beta-CD solid complexes were prepared by the novel approach of microwave irradiation (MWI) followed by three different drying methods: vacuum oven drying (VO), freeze drying (FD) or spray drying (SD). Quantification of the solid complexes formed pointed to the not involving heat, FD, as the best drying method, followed by VO and SD, which led to significantly lower amounts of encapsulated essential CO.